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KMID : 0616120160470030280
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 3 p.280 ~ p.286
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Lifespan Extending Effects of Helianthus tuberosus Linne in C. elegans
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Lee Byung-Ju
Yoon Young-Jin
Oh Jong-Woo
Park Zi-Won
Lee Hyun-Joo
Kim Yong-Sung
Cha Dong-Seok
Kwon Jin
Oh Chan-Ho
Jeon Hoon
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Abstract
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Helianthus tuberosus Linne (Compositae) has been widely used as a folk remedy to treat various ailments including fever, bleeding, fracture and contusion. This study was designed to elucidate the lifespan extending activities MeOH extract of the tubers of Helianthus tuberosus Linne (MHT) using Caenorhabditis elegans (C. elegans) model system. In the current study, we found that the lifespan of worms was significantly extended by MHT supplement, dose-dependently. MHT also provided robust protection against various stress environments such as osmotic, thermal and oxidative condition. In addition, elevated antioxidant enzyme activities by MHT resulted in attenuation of intracellular reactive oxygen spices (ROS) levels, suggesting antioxidant capacity of MHT might be associated with longevity properties. Herein, we showed that altered food intake and growth of worms were also involved in the MHT activity. Furthermore, MHT increased body movement in aged worms, indicating possible role for MHT in healthspan.
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KEYWORD
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Helianthus tuberosus Linne , Lifespan , Stress tolerance , Caecorhabditis elegans , Healthspan
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